Sustained Release of hCG Minipellet for Newt Experiment in Space

Abstract

Sustained release formulation of hCG, hCG minipellet, was applied to induce oviposition of newt. Period of egg spawning was prolonged with a certain delay of its initiation. When hCG minipellet was injected to newt that was hibernating, it induced egg spawning even after one month of hibernation. Results suggest that minipellet keeps steady concentration of hCG at the effective level for longer period. For the study on early development of newt egg, it is essential to obtain egg on orbit. hCG minipellet makes it possible even at launch slip or early “late access”.