Simvastatin downregulated C35 expression and inhibited the proliferation of colon cancer cells Lovo and HT29 in vitro

Min Li; Yong Huang; Xuan Dong; Qingkuan Wei; Jin Li; Hui Sun; Chenchen Li; Conghu Qi; Jingyu Yang

doi:10.5582/bst.2016.01025

Brief Reports

Simvastatin downregulated C35 expression and inhibited the proliferation of colon cancer cells Lovo and HT29 in vitro

Min Li, Yong Huang, Xuan Dong, Qingkuan Wei, Jin Li, Hui Sun, Chenchen Li, Conghu Qi, Jingyu Yang

Author information

Min Li
Shandong Academy of Medicine Sciences, Shandong Provincial Institute of Parasitic Diseases
School of Medicine and Life Sciences, Ji’nan University, Shandong Academy of Medicine Sciences
Yong Huang
Shandong Academy of Medicine Sciences, Shandong Provincial Institute of Parasitic Diseases
Xuan Dong
Shandong Academy of Medicine Sciences, Shandong Provincial Institute of Parasitic Diseases
Qingkuan Wei
Shandong Academy of Medicine Sciences, Shandong Provincial Institute of Parasitic Diseases
Jin Li
Shandong Academy of Medicine Sciences, Shandong Provincial Institute of Parasitic Diseases
Hui Sun
Shandong Academy of Medicine Sciences, Shandong Provincial Institute of Parasitic Diseases
Chenchen Li
Shandong Academy of Medicine Sciences, Shandong Provincial Institute of Parasitic Diseases
School of Medicine and Life Sciences, Ji’nan University, Shandong Academy of Medicine Sciences
Conghu Qi
Zoucheng People’s Hospital
Jingyu Yang
Shandong Academy of Medicine Sciences, Shandong Provincial Institute of Parasitic Diseases

Keywords: Colon cancer, C35, simvastatin, mevalonate, HMG-CoA

JOURNAL FREE ACCESS

2016 Volume 10 Issue 3 Pages 227-230

DOI https://doi.org/10.5582/bst.2016.01025

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Abstract

The aim of this study was to investigate the antitumor effect of simvastatin in human colon cancer and the possible underlying mechanism. We found that simvastatin dose-dependently inhibited the proliferation of human colon cancer cells Lovo and HT29 using a MTT assay. Real-time PCR and Western blotting assays showed that simvastatin significantly suppressed C35 expression at both mRNA and protein levels. Since C35 is known to have a significant oncogenic role in cancer development via promoting cell proliferation and migration, results obtained in the current study imply that downregulation of C35 expression might be involved in the antitumor effect of simvastatin on colon cancer.

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