Association of HIV infection with metabolic syndrome among normal or underweight young adults: evidence from the CHART cohort

Ruizi Shi; Xiaoxiao Chen; Haijiang Lin; Weiwei Shen; Xiaohui Xu; Bowen Zhu; Xiaoyi Xu; Yingying Ding; Frank Y. Wong; Na He

doi:10.5582/bst.2020.03351

Brief Report

Association of HIV infection with metabolic syndrome among normal or underweight young adults: evidence from the CHART cohort

Ruizi Shi, Xiaoxiao Chen, Haijiang Lin, Weiwei Shen, Xiaohui Xu, Bowen Zhu, Xiaoyi Xu, Yingying Ding, Frank Y. Wong, Na He

著者情報

Ruizi Shi
School of Public Health, Fudan University, Shanghai, China; and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.
Key Laboratory of Health Technology Assessment of Ministry of Health, Fudan University, Shanghai, China.
Xiaoxiao Chen
Taizhou City Center for Disease Control and Prevention, Zhejiang Province, China.
Haijiang Lin
School of Public Health, Fudan University, Shanghai, China; and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.
Taizhou City Center for Disease Control and Prevention, Zhejiang Province, China.
Weiwei Shen
Taizhou City Center for Disease Control and Prevention, Zhejiang Province, China.
Xiaohui Xu
School of Public Health, Fudan University, Shanghai, China; and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.
Bowen Zhu
School of Public Health, Fudan University, Shanghai, China; and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.
Xiaoyi Xu
School of Public Health, Fudan University, Shanghai, China; and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.
Yingying Ding
School of Public Health, Fudan University, Shanghai, China; and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.
Frank Y. Wong
School of Public Health, Fudan University, Shanghai, China; and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.
Center for Indigenous Nursing Research for Health Equity, Florida State University, Tallahassee, FL, U.S.A.
Department of Psychology, College of Social Sciences, University of Hawai'i at Mānoa, Honolulu, HI, U.S.A.
Department of Population Science, John D. Bower School of Population Health, University of Mississippi Medical Center, MS, U.S.A.
Na He
School of Public Health, Fudan University, Shanghai, China; and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.
Key Laboratory of Health Technology Assessment of Ministry of Health, Fudan University, Shanghai, China.

キーワード: metabolic syndrome, body mass index, young adults, HIV infection, China

ジャーナルフリー

2020 年 14 巻 6 号 p. 450-456

DOI https://doi.org/10.5582/bst.2020.03351

Browse “Advance online publication” version

詳細

抄録

Metabolic syndrome (MS) is common among obese people. Little is known about the magnitude and characteristics of MS in people living with HIV (PLWH) in Asian countries in general and China in particular. Using baseline data collected between February 2017 through January 2020 from the Comparative HIV and Aging Research in Taizhou (CHART) cohort in China, we examined MS among 2,227 PLWH and 5,264 matched people without HIV, respectively. MS was defined using the criteria set forth by the International Diabetes Federation (IDF). Approximately 76.7% of PLWH had body mass index (BMI) < 24.0 kg/m², significantly higher than people without HIV (50.3%). Among participants with BMI < 24.0 kg/m², PLWH had a significantly higher prevalence of MS than people without HIV (20.6% vs. 14.5%; aOR: 1.41, 95% CI: 1.19-1.68) overall, and at an age of 18-29 (10.4% vs. 3.4%, aOR: 3.49, 95% CI: 1.99-6.11) and 30-44 years (17.3% vs. 8.5%, aOR: 2.03, 95% CI: 1.47-2.81), respectively. Among participants with BMI ≥ 24.0 kg/m², MS prevalence was not significantly different between PLWH and people without HIV overall, but significantly lower in PLWH than people without HIV for those aged over 60 years (65.9% vs. 77.8%, aOR: 0.53, 95% CI: 0.32-0.88). Among PLWH, MS was significantly associated with older age and higher CD4 cell count, and with stavudine (d4T) use only in the group of BMI < 24.0 kg/m². Our finding is indicative of a relatively higher risk for early onset of MS among HIV-infected young adults with lower BMI. Research is needed to elucidate the pathogenic mechanism for MS among PLWH.

責任著者(Corresponding author)