BioScience Trends
Online ISSN : 1881-7823
Print ISSN : 1881-7815
ISSN-L : 1881-7815
Letter
Zbtb7a and Zbtb7b: Opening naïve loci to reprogram ESCs
Hua CaoHong HuangHuifang Tang
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JOURNAL FREE ACCESS

2021 Volume 15 Issue 1 Pages 58-60

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Abstract

Bone morphogenetic protein 4 (BMP4) was recently reported to confer reprogramming capability to embryonic stem cells (ESCs) by reactivating naïve pluripotency genes via Zbtb7a and Zbtb7b. A visual reporting system was developed to first identify BMP4 as a driver for the primed-to-naïve transition (PNT). In addition, two specific inhibitors were identified as significantly improving the efficiency of PNT (~80% transition) within 8 days. The Zbtb7 family members were first introduced in the context of PNT and stem cell fate decision-making. These findings provide valuable information on acquiring naïve pluripotent stem cells for regenerative medicine.

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© 2021 International Research and Cooperation Association for Bio & Socio-Sciences Advancement
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