BioScience Trends
Online ISSN : 1881-7823
Print ISSN : 1881-7815
ISSN-L : 1881-7815
Original Article
Anti-neuroinflammatory activity of Shenqi Fuzheng Injection and its main active constituents
Wenwen WangZijia ZhangYanping DengZhixin YangJinjun HouHuali LongMin LeiWanying Wu
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JOURNAL FREE ACCESS

2021 Volume 15 Issue 4 Pages 231-239

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Abstract

Enhancement of alternative activation (M2) in microglia is a promising therapeutic target for microglia-mediated neuroinflammation. Shenqi Fuzheng Injection (SFI) is a clinical adjuvant treatment for cancer to reduce the side effects during cancer treatment, including boosting mood and improving appetite. However, the mechanism of SFI's effects on central symptoms is not clear. Therefore, using arginase 1 (Arg1) and transforming growth beta-1 (Tgfb1) as markers for M2 microglia activation, we found that compounds 1, 5, 12, 14, and 15 are the major M2-promoting constituents in SFI, which significantly upregulated Arg1 or Tgfb1 gene expression. Our results suggested that these compounds in SFI may promote M2 microglial activation and have potential uses in modulating microglial activation and alleviating neuroinflammation.

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© 2021 International Research and Cooperation Association for Bio & Socio-Sciences Advancement
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