BioScience Trends
Online ISSN : 1881-7823
Print ISSN : 1881-7815
ISSN-L : 1881-7815
Brief Reports
Effect of c-Met inhibitor SU11274 on hepatocellular carcinoma cell growth
Yoshinori InagakiFanghua QiJianjun GaoXianjun QuKiyoshi HasegawaYasuhiko SugawaraWei TangNorihiro Kokudo
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ジャーナル フリー

2011 年 5 巻 2 号 p. 52-56

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抄録
c-Met, a type of receptor tyrosine kinase, may be significantly associated with the progression of hepatocellular carcinoma (HCC). In addition, des-γ-carboxyprothrombin (DCP) has been found to interact with c-Met and activate HCC cell growth. Therefore, the functional inhibition of c-Met expressed on HCC cells should arrest HCC cell growth. The present study found that the c-Met inhibitor SU11274 suppressed HCC cell growth by inhibiting the activation of c-Met. Furthermore, this inhibitor also neutralized the activation of HCC cell growth resulting from the addition of DCP. These results suggest that the functional inhibition of c-Met might be a target for the development of chemotherapeutic agents for HCC, and especially those that are positive for expression of DCP.
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© 2011 International Research and Cooperation Association for Bio & Socio-Sciences Advancement
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