BioScience Trends
Online ISSN : 1881-7823
Print ISSN : 1881-7815
ISSN-L : 1881-7815
Letter
Proposed interaction between angiotensinogen and retinoblastoma tumor suppressor protein: Potential molecular origin of hypertension
Razvan T. Radulescu
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JOURNALS FREE ACCESS

2012 Volume 6 Issue 6 Pages 340-341

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Abstract

Hypertension ranks among the most important disease challenges on a global scale. Here, a novel hypothesis is presented which implicates angiotensinogen, i.e. the precursor protein for the hypertensive peptide angiotensin II, as a key culprit in the pathogenesis of hypertension. This hypothesis more precisely entails that intracellular angiotensinogen binds and thereby inactivates the retinoblastoma tumor suppressor protein (RB), consequently leading to an inflammatory and hyperproliferative state that significantly contributes to pathologically increasing blood pressure. Accordingly, a conceivable antihypertensive strategy could comprise RBderived compounds that neutralize angiotensinogen.

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© 2012 International Research and Cooperation Association for Bio & Socio-Sciences Advancement
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