BioScience Trends
Online ISSN : 1881-7823
Print ISSN : 1881-7815
ISSN-L : 1881-7815
Original Articles
Prognostic significance of β-catenin expression in patients with non-small cell lung cancer: A meta-analysis
Xiaodong MeiHong SuJian SongLiang Dong
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JOURNALS FREE ACCESS

2013 Volume 7 Issue 1 Pages 42-49

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Abstract

β-Catenin has been reported to play a crucial role in the invasion and metastasis of lung cancer. However, the value of β-catenin as a prognostic factor for non-small cell lung cancer (NSCLC) remains controversial. The present study systematically reviewed the evidence of predicting significance of β-catenin expression in NSCLC patients with meta-analysis. Twelve literatures were included by searching PubMed, Cochrane library, and EMBASE databases. Separate hazard ratio estimates and a 95% confidence interval (CI) for the prognostic value of β-catenin in NSCLC were extracted and merged from the included literatures. The summary hazard ratios were 1.91 (95% CI 1.60-2.28), indicating a worse overall survival for NSCLC patients with reduced β-catenin expression. There Publication bias was not statistically significant. Sensitivity analysis showed that omission of any single study had little effect on the combined risk estimates. This meta-study revealed that decreased β-catenin expression denoted a poor prognosis in NSCLC patients.

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© 2013 International Research and Cooperation Association for Bio & Socio-Sciences Advancement
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