BioScience Trends
Online ISSN : 1881-7823
Print ISSN : 1881-7815
ISSN-L : 1881-7815
Review
The role of nerve growth factor and its receptors in tumorigenesis and cancer pain
Wenfang WangJinhua ChenXiuli Guo
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JOURNALS FREE ACCESS

2014 Volume 8 Issue 2 Pages 68-74

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Abstract

The nerve growth factor (NGF) is a growth factor that belongs to the neurotrophin family. NGF has two structurally different receptors, the p75 neurotrophin receptor (p75NTR) and the tropomyosin-related kinase A (TrkA). Interaction of NGF with its receptors regulates a variety of physiological processes of neuronal system. Recent studies have shown that NGF and its receptors were involved in the regulation of tumourigenesis by either supporting or suppressing tumor growth depending on the tumor types. This review summarizes the current views of NGF and its receptors in tumorigenesis and cancer pain.

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© 2014 International Research and Cooperation Association for Bio & Socio-Sciences Advancement
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