BioScience Trends
Online ISSN : 1881-7823
Print ISSN : 1881-7815
ISSN-L : 1881-7815
Reviews
The role of autophagy in bacterial infections
Nayeli Shantal Castrejón-JiménezKahiry Leyva-ParedesJuan Carlos Hernández-GonzálezJulieta Luna-HerreraBlanca Estela García-Pérez
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JOURNAL FREE ACCESS

2015 Volume 9 Issue 3 Pages 149-159

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Abstract

Autophagy is a highly conserved catabolic process for the degradation of cytosolic components including damaged organelles, protein aggregates, and intracellular bacteria through a lysosome-dependent pathway. Autophagy can be induced in response to stress conditions. Furthermore, autophagy has been described as involved in both innate and adaptive immune responses, and several studies have shown that certain microorganisms can be eliminated by the autophagic route in a process known as xenophagy. However, several pathogens have developed different strategies to evade or exploit autophagy to ensure their survival. Here, we review the role of autophagy in response to bacterial pathogens.

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© 2015 International Research and Cooperation Association for Bio & Socio-Sciences Advancement
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