THE BULLETIN OF TOKYO MEDICAL AND DENTAL UNIVERSITY
Online ISSN : 2435-0761
Print ISSN : 0040-8921
ACUTE SODIUM FLUORIDE TOXICITY IN THE RAT KIDNEY
Minoru TAKAGIShoko SHIRAKI
著者情報
ジャーナル オープンアクセス

1982 年 29 巻 4 号 p. 123-130

詳細
抄録
Acute sodium fluoride toxicity was studied histologically and histochemically in the rat kidney. The doses given subcutaneously by a single injection were 10, 12.5 and 15 mg/100 gm of body weight and the duration after the administration were 30 minutes, and one, 3, 5 and 7 days. Histologically, coagulation necrosis of the proximal tubules was found at I day and the injury was most striking at 3 days. Regeneration was almost complete at 7 days. Among the enzymes studied, e.g., alkaline phosphatase, acid phosphatase, 5'-nucleotidase, adenosine triphosphatase and succinic dehydrogenase, the acid phosphatase of the tubular epithelium was the most severely impaired.
著者関連情報
© 1982 Tokyo Medical and Dental University (TMDU)
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