Abstract
Supramolecular recognition provides two effective approaches, which offer chirality sensing of biological substrates using circular dichroism (CD) spectroscopy: (1) sophisticated receptors having highly complementary binding sites to targeted guests, and (2) programmed aggregates integrating the chirality up to the supramolecular level. The conjugation of 18-crown-6 and characteristic binding sites has typically attained chirality sensing of amino acids via synergistic binding, while highly structured polymers or amphiphiles have led to chirality sensing upon ordered aggregation. Since these supramolecular systems have broad structural variations, intelligent chirality sensing can be built up via further molecular architecture.
