GANN Japanese Journal of Cancer Research
Print ISSN : 0016-450X
THE RELATIONSHIP BETWEEN THE PEPTIDE STRUCTURE AND THE IMMUNOLOGICAL ACTIVITY OF THE SERUM ALBUMIN OF PATIENTS WITH CARCINOMA
Eiichi FUJIWARA
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1962 Volume 53 Issue 2 Pages 159-165

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Abstract
(1) Chromatographic analysis of tryptic hydrolysate of cancer albumin suggests the possible mechanism of the tumor tissue taking up the specific peptide constituent from albumin molecule and synthesizing the same peptide and putting it into albumin molecule.
(2) The serum albumin obtained from a cancer patient has the characteristic antigen which is able to produce, in 50% of the cases, anaphylactic contraction of the intestinal strip of a rat immunized by cancer albumin.
(3) The structural change produced during the time between the entry of albumin into the tumor and the leaving from it might give the cancer albumin antigenicity different from the normal albumin.
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© The Japanese Cancer Association
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