Abstract
6-Chloro-4-nitroquinoline 1-oxide was demonstrated to possess a very powerful carcinogenic action. Applied to the rat skin two times a week, the substance in 0.5% acetone solution produced malignant tumors which were histologically fibrosarcoma (12 cases), fibrosarcoma associated with basal cell carcinoma (5 cases), and fibrosarcoma associated with sweat gland adenoma (1 case). Metastases were found in a few cases but transplantation was not attempted.
6-Chloro-4-nitroquinoline 1-oxide is apparently a more powerful carcinogen than 4-nitroquinoline 1-oxide and this fact was discussed in relation to the theory that substitution of a nitro group at 4-position with thiol compounds may be the essential chemical reaction which determines the carcinogenic activity of these related derivatives.
