Abstract
1) Mouse liver catalase was inhibited by 3-amino-1, 2, 4-triazole, allylisopropylacetamide (AIA), and allylisopropylacetylcarbamide (AIC) just as in the rat, the effective doses being proportional to the body weight.
2) The rate of destruction (kD) of mouse liver catalase lies around 0.020 with 3-amino-1, 2, 4-triazole, AIA, and AIC alike.
3) Continued administration of toxohormone did not decrease the level of catalase activity progressively as in the case of AIA or AIC, and this activity remained at a certain low level (around 70% of the control). Several possibilities to account for this phenomenon are discussed.
4) Whether the liver catalase depression by toxohormone is due to the increased rate of its destruction or the decreased rate of its synthesis was analysed with the aids of 3-amino-1, 2, 4-triazole, AIA, and AIC.
It is substantiated from various experiments that the depression of liver catalase by toxohormone injection is mainly due to the decreased rate of its synthesis.
