INDUCTION AND TRANSPLANTATION OF CANCER OF THE LUNG IN RATS

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Cancers of the lung were induced by the repeated subcutaneous injections of 4-nitroquinoline 1-oxide in three groups of rats receiving a total amount of 15, 11, and 7.25mg, respectively. The lung cancer was found in 16 (37.2%) out of 43 effective rats that survived more than 223 days. These cancers were usually adenocarcinomas (30.2%), but there were also some epidermoid carcinomas (7.0%). Both adenocarcinoma and epidermoid carcinoma gave rise to metastases in distant organs. Almost all the rats had multicentric pulmonary adenomas. Various degrees of hyperplasia and metaplasia of bronchial epithelia or alveoli were also observed. Subcutaneous sarcomas often arose in the area of application of the carcinogen. A transplantable strain of the epidermoid carcinoma was separated successfully.