A large dose of Mitomycin-C was given during gastrectomy and on the first postoperative day in 489 gastric cancer patients. Both from the analysis of the postoperative complications and from the post-operative mortality, the harmlessness of this method was shown. The intermediate results of gastrectomy were investigated in 515 non-curative gastrectomy cases. The cases in which a large-dose administration of Mitomycin-C was carried out during gastrectomy showed an excellent survival rate at 6, 12, and 18 months after the operation as compared with the control group. The transplantation of homologous bone marrow cells seems to diminish the possibility of recurrence in enhancing the effect of chemotherapy, and its mechanism was discussed.
