INDUCTION OF MALIGNANT LYMPHOMA AND OTHER TUMORS DURING EXPERIMENTS WITH ANTHRALIN PAINTING OF MICE
1968 Volume 59 Issue 3 Pages 195-200_3
Details
1968 Volume 59 Issue 3 Pages 195-200_3
During experiments with skin papilloma production in mice, many animals died unexpectedly due to lymphomas or other tumors. Malignant lymphomas appeared in ICR mice treated with daily paintings of Anthralin (1, 8, 9-trihydroxyanthracene) in acetone. The incidence of such tumors increased by intraperitoneal injection(s) of urethan prior to the first painting; over one-half of these animals developed tumors within 28 weeks. Many superficial and some deep lymph nodes were affected, and the thymus, liver, spleen, and kidneys were infiltrated by tumor cells, extensively in some cases. Histological examination showed marked proliferation of stem-cells and/or lymphoblasts.
Thymomas and lung adenomas were also induced. Mammary carcinoma appearing frequently in CFW mice was thought to be spontaneous and not induced.
