HISTOGENESIS OF CHOLANGIOFIBROSIS AND WELLDIFFERENTIATED CHOLANGIOCARCINOMA IN SYRIAN HAMSTERS GIVEN 2-ACETAMIDOFLUORENE OR 2-DIACETAMIDOFLUORENE

Abstract

Cholangiofibrosis and cirrhosis preceded the development of well-differentiated cholangiocarcinomas in male and female hamsters given 2-acetamidofluorene or 2-diacetamidofluorene in a semi-synthetic diet. The lesions could be followed from proliferation of new bile ducts to cholangiofibrosis, cholangiofibrosis with atypical cells, small cholangiocarcinomas, and cholangiocarcinomas with metastases. Few of the early lesions progress to the stage of carcinomas; most develop degenerative changes.