METABOLISM OF 4-NITROQUINOLINE 1-OXIDE

IV. QUANTITATIVE DETERMINATION OF IN VIVO CONVERSION OF 4-NITROQUINOLINE 1-OXIDE IN SUBCUTANEOUS TISSUE OF RAT

Abstract

4-Nitroquinoline 1-oxide, injected subcutaneously into rats, rapidly disappeared from the injected site. The amount of 4-hydroxyaminoquinoline 1-oxide, metabolically formed from 4-nitroquinoline 1-oxide, reached the maximum after one hour, and remained in the injected site at least for 24 hours. 4-Aminoquinoline 1-oxide was detected in a very small amount.