IMMUNOLOGICAL RESPONSE OF ADOPTIVE TRANSFER FOR THE GROWTH OF YOSHIDA SARCOMA

Abstract

The lymph node cells, spleen cells, thymus cells, and bone marrow cells were prepared from Yoshida sarcoma-resistant rats produced by Mitomycin-C administration and strengthened by challenge of the same tumor. A certain number of these immune cells was transplanted into isologous and allogeneic rats by intravenous or intraperitoneal injection. Then, 10⁵ Yoshida sarcoma cells were injected intraperitoneally on the 2nd, 8th, 20th, and 60th day. The survival rate of the recipients was the highest in the group which received inoculations on the 8th day, and even in the group receiving inoculations on the 60th day, host resistance was recognized by transfer of immune cells against Yoshida sarcoma. There was no difference in the tumor-resistance between the isologous and allogeneic immune cell transfer. When the number of immune cells was increased, survival rate of the recipients also increased. The relationship between transfer of immune cells and R-factor, one of the histocompatibility genes of rats, was discussed.