DISTRIBUTION OF N-METHYL[¹⁴C]-BIS(3-MESYLOXYPROPYL)-AMINE HYDROCHLORIDE AND ITS METABOLITES IN NORMAL AND TUMOR-BEARING RATS

Abstract

Distribution of N-methyl[¹⁴C]-bis(3-mesyloxypropyl)amine hydrochloride in the tissue was studied with normal and tumor-bearing rats. The tumors investigated were original and a resistant subline of Yoshida sarcoma, and a rat ascites hepatoma AH-7974, Higher radioactivity content was found in general in all the tissues of tumor-bearing rats than those of normal rats under the same dose of administration. The compound showed somewhat specific affinity to the kidney, intestine, spleen, liver, and tumors. Incorporation of radioactivity into the ascites tumor cells of a resistant subline of Yoshida sarcoma and AH-7974 at 1 hour after injection of the compound was, however, about one-half and one-third of that into Yoshida sarcoma cells but there was no marked difference in the case of solid tumor among the three kinds of tumor examined.