ANTITUMOR EFFECT OF ACTINOMYCIN-D ON TRANSPLANTABLE WILMS TUMOR IN RATS

Abstract

Antitumor effect of Actinomycin-D was studied using six strains of transplantable Wilms tumor and ascites hepatoma AH-130 in rats. Four strains which retained the histological feature of Wilms tumor were most susceptible to Actinomycin-D and the growth rate was inhibited, resulting in a definite prolongation of the life span of host animals. However, no prolongation of life span was observed in AH-130 and two strains of Wilms tumor which were already sarcomatous in the histological pattern, though a slight inhibition in their growth rate was observed.