Abstract
Effect of anticancer drugs on DNA synthesis and mitotic cycle of rat liver cells during the period of regeneration after partial hepatectomy was investigated by autoradiography with tritiated thymidine and biochemical analysis. A single injection of Mitomycin-C or Chromomycin-A3 depressed DNA synthesis and mitosis if the drug was given before extensive DNA synthesis took place. Cyclophosphamide or thio-TEPA did not depress DNA synthesis but suppressed cell division significantly. The inhibitory activity of Mitomycin-C proved most effective in comparison with those of other anticancer agents.
