Abstract
A simplified method for determination of hormones responsible for breast cancer was studied using tumor slices in vitro. Uptake of 32P into nucleic acid of tumor slices was elevated by the addition of dependent hormones. Mammary tumors of C3H mice are highly dependent on steroid hormones. 32P uptake into nucleic acid of C3H mammary tumor was elevated by 17β-estradiol and cortisol, and was suppressed by progesterone and testosterone propionate.
Breast cancer patients were divided into three groups of hormone-dependent, hormone-independent, and hormone-sensitive. In hormone-dependent or -sensitive breast cancer, addition of the corresponding hormones influenced 32P uptake into nucleic acid of tumor slices. From these results, the preferable postoperative treatments for breast cancer were suggested.
