RESONANCE TRANSFER OF EXCITATION ENERGY BETWEEN AROMATIC AMINO ACIDS AND CARCINOGENIC AROMATIC COMPOUNDS AS A POSSIBLE MECHANISM IN CARCINOGENESIS
1969 年 60 巻 5 号 p. 469-481
詳細
1969 年 60 巻 5 号 p. 469-481
In order to illustrate the carcinogenesis of various carcinogenic aromatic compounds uniformly at a molecular level, extension of the theory of Birks was investigated; the overlap integral J of the resonance transfer between aromatic amino acids and 85 kinds of carcinogenic aromatic compounds or 77 kinds of noncarcinogenic aromatic compounds was calculated. J values of carcinogenic aromatic compounds were compared with those of noncarcinogenic aromatic compounds and the J values of carcinogens were found to disperse in some constant region. The relationship between J values of carcinogenic aromatic compounds and their carcinogenic activity was examined and the rank correlations were found to be highly significant only in the case of tryptophan.
