CARCINOMAS OF THE GLANDULAR STOMACH AND OTHER ORGANS OF RATS BY 4-HYDROXYAMINOQUINOLINE 1-OXIDE HYDROCHLORIDE

Abstract

By intragastric instillation of 4-hydroxyaminoquinoline 1-oxide hydrochloride in ethanol solution, tumors of the glandular stomach, mammary glands, thymus, uterus, and small intestine were induced in Buffalo rats. Concerning neoplastic lesions of the glandular stomach, two cases (7.1%) of advanced adenocarcinoma, 1 case (3.6%) of signet ring cell carcinoma with submucosal invasion, and 4 cases (14.3%) of mucosal carcinoma were obtained out of 28 effective animals.