抄録
Three hundred and seventy-three surgically resected ulcers of the stomach, comprising both open active and healed inactive ulcers, were histologically examined with close attention on the structural alteration in microscopical appearance in different states of ulcer. In open active ulcers, the histological pictures frequently observed were (1) thick necrotic layer and (2) absence of regenerates, fusion, and granulation tissue. In the healed ulcers, they were (1) presence of regenerates and fusion, and (2) involusion of fibrosis. The results were confirmed by histological examination of 27 ulcers, which had been proved as active or healed by retrospective study of a series of X-ray and gastrocamera films. It is likely that the histological appearance of gastric ulcer may differ according to pendulation from open ulcer to healed ones. The elements of "histological criteria of ulcer-cancer", such as the breach of musculares, fusion, fibrosis, and regenerates, are proved not to be stable and unchangeable findings. It is probable that they can be produced within a short period of time, and that they can disappear within a short time. Presence of these pictures in a gastric ulcer does not always indicate the long standing of the lesion, but merely shows the state of ulcer whether it is inclined toward healing or toward ulceration. These histological pictures, therefore, may not provide any reliable basis for histological criteria of ulcer-cancer.
