MANIFOLD CHROMOSOME OBSERVATIONS IN ACUTE MYELOGENOUS LEUKEMIA
1971 年 62 巻 4 号 p. 301-308
詳細
1971 年 62 巻 4 号 p. 301-308
Chromosomes were studied in blood and marrow cells of 10 patients with acute myelogenous leukemia, under several different observational conditions, i.e., in direct preparations and in cultures with and without phytohemagglutinin.
Abnormal karyotypes were observed in 5 cases; 2 cases with a presumptive C/G translocation, 1 case showing a Ph1-like chromosome, 1 hyperdiploid case having 52 chromosomes, and 1 case characterized by a ring chromosome. The remaining 5 cases showed a normal karyotype.
Although direct marrow preparations were of potential value for cytogenetic analysis of leukemic cells, blood and marrow cultures without phytohemagglutinin were also useful for detection of abnormal karyotypes undetectable by the direct method as well as for the evaluation of chromosomally normal leukemic cells.
