1971 Volume 62 Issue 5 Pages 359-365_2
The effect of unilateral ureter ligation on the development of tumors in the renal pelvis, ureter, and urinary bladder of male Wistar strain rats treated with N-butyl-N-(4-hydroxybutyl)nitosoamine was investigated. The activities of β-glucuronidase in homogenates of liver, kidney, and bladder of rats after unilateral ureter ligation were also examined. The incidence of kidney and ureter tumors in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosoamine was much higher after ligation of one ureter. The present reuslts showed that unilateral ligation of the ureter was a good method to induce transitional cell carcinomas in the kidney and ureter of rats treated with N-butyl-N-(4-hydroxybutyl)nitrosoamine. Hyperplasia of the epithelium of the renal pelvis and ureter was occasionally seen in carcinogen-treated rats. It was suggested that the hyperplastic changes were precursors of transitional cell carcinoma of the renal pelvis and ureter in rats receiving N-butyl-N-(4-hydroxybutyl)nitrosoamine. The activity of β-glucuronidase was raised in tumors of the urinary bladder but the activity of this enzyme in liver and kidney tissues was not influenced by the administration of N-butyl-N-(4-hydroxybutyl)nitrosoamine.
