SHIFT OF TARGET ORGANS IN CYCASIN CARCINOGENESIS

Abstract

Oral administration of cycasin in various dosage schedules resulted in tumor induction in different organs of the rats. In one group, a small dose of cycasin was administered continuously. A considerable number of mammary cancer was detected in Sprague-Dawley female rats and interstitial cell tumors of the testis in ACI males. Acceleration of spontaneous tumor induction was suspected. Multiple pulse doses and a large single dose of cycasin were administered to other groups. Tumors of the intestine and kidney were observed in high incidence in these experiments. Cirrhosis of the liver was found exclusively in the pulse-dose group.