FREQUENT DEVELOPMENT OF OVARIAN TUMORS FROM DYSGENETIC OVARIES OF NEONATALLY THYMECTOMIZED MICE

Abstract

Ovarian dysgenesis characterized by deletion of follicles and corpora lutea can be induced by neonatal thymectomy in mice. It is demonstrated that development of granulosa cell tumors from the dysgenetic ovaries is obseved in ca. 40% of thymectomized mice after the age of 15 months without any exogeneous carcinogenic stimulation.