INDUCTION OF RAT OSTEOSARCOMA BY INOCULATION OF MURINE SARCOMA VIRUS INTO BONE MARROW

Abstract

Rat osteosarcoma was induced by inoculation of murine sarcoma virus (Moloney) into the tibial bone marrow of neonatal rats at a high frequency and in a relatively short period. Radiography revealed largely osteoplastic changes in the metaphyses of tibial bones. These osteosarcomas showed close similarity to the human one, both histologically and radiographically.