IMPAIRED SYNTHESIS OF LIVER CATALASE IN TUMOR-BEARING RATS

Abstract

Depressed synthesis of liver catalase in rats bearing ascites hepatoma cells (AH-49 WH) was examined and the evidences obtained were (1) lower incorporation of injectded ¹⁴C-leucine into liver catalase, (2) decrease in the amount of catalasesynthesizing ribosomes in liver, and (3) impaired synthesis of liver catalase in cell-free system.
These results strongly support the conclusion from immunochemical assay of catalase that the decrease of hepatic catalase activity in tumor-bearing rats is caused by the depression of its biosynthesis.