CARCINOGENESIS BY VAGINAL TRANSPLANTS FROM OVARI-ECTOMIZED, NEONATALLY ESTROGENIZED MICE INTO OVARIECTOMIZED NORMAL HOSTS

Abstract

Basal cell carcinomas occurred in the epithelium of the vagina transplanted from old ovariectomized mice receiving neonatal estrogen injections into ovariectomized "normal" mice after residence of more than 2 years in the hosts. Neither hyperplasia nor proliferation took place in the epithelium of vaginal transplants if the donor had not been estrogenized during neonatal life. Following serial transfer, the carcinoma metastasized to the mesentery and the pancreas. The possible relation between vaginal carcinogenesis and irreversible proliferation of the vaginal epithelium induced by neonatal treatment with estrogen was discussed.