ENHANCEMENT OF RADIATION EFFECT ON TRANSFORMED FIBROBLASTIC CELLS BY A SYNERGISTIC COMBINATION OF 5-FLUOROURACIL AND POLYENES IN VITRO

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Using cultured transformed fibroblasts (RFL-T), an antitumor agent, 5-fluorouracil, was found to be potentiated in its inhibitory action on RNA formation by vitamin A as well as Amphotericin-B. 5-Fluorouracil in combination with vitamin A or Amphotericin-B enhanced more effectively the cellular sensitivity to cobalt radiation than when 5-fluorouracil was used alone.