CAFFEINE POTENTIATION ON LETHALITY OF L-1210 CELLS TREATED WITH NEOCARZINOSTATIN

Abstract

The caffeine potentiation on lethality of L-1210 cells treated with Neocarzinostatin was studied. Colony formation of L-1210 cells treated with Neocarzinostatin was significantly decreased by incubation tofhe cells for 48hr with 0.5mM of caffeine which alone did not affect the growth rate and colony-forming ability of the cells. These results indicate that Neocarzinostatin may induce repairable damage in DNA of L-1210 cells.