PERSISTENT NUCLEOLI IN CULTURED YOSHIDA SARCOMA CELLS EXPOSED TO A SERIES OF CARCINOGENIC AND NONCARCINOGENIC DERIVATIVES OF 4-NITROQUINOLINE 1-OXIDE

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The frequency of persistent nucleoli increased in the Yoshida sarcoma cells treated in vitro with 4-nitroquinoline 1-oxide. Carcinogenic derivatives of 4-nitroquinoline 1-oxide seem to increase the frequencv of persistent nucleoli, compared to noncarcinogenic derivatives.