2015 Volume 26 Issue 2 Pages 107-112
In order to elucidate the mechanisms of cerebral aneurysmal development, growth and rupture, animal models are requisite. The models include 1) direct injury models against arterial walls by direct surgical procedures, and 2) indirect induced models by burdening aneurysm-induction factors. The latter model can induce characteristic histological features similar to human cerebral aneurysms such as disappearance of internal elastic lamina and destruction of smooth muscle layer, and is useful for analyzing pathogenesis of the lesion. We have introduced rat and monkey models by performing unilateral common carotid occlusion and renal artery occlusion with bilateral oophorectomy and fed by high salt diet with a collagen synthesis inhibitor. Possible medical treatments against cerebral aneurysm development are discussed.
