Dose response to 5-fluor0-2'-deoxycytidine in organogenesis of the golden hamster

抄録

In proceeding with the comparative investigations with 5-fluoro-2'-deoxycytidine (F-CdR) in inbred mice we used a strain of random bred golden hamsters maintained for years at our laboratory and tested the embryotoxic and teratogenic dose response relations at stage day IX of pregnancy. It could be stated that the status of differentiation at stage day IX of pregnancy may be externally comparable with day X in the mouse (C57BL/6 and C57BL/10) except for some features. In experimental series attention was focused mainly on the skeletal system, i.e. the skull, the vertebral column and the limbs. Primordia of the vertebral column reacted most, while those of the skull reacted least. Analogous to the earlier investigation with mice we defined types of multiple regional skeletal defects of the three main parts. Animals with defects in all three main parts of the skeleton were the most frequent, whereas the combination of defects of limbs and vertebral column had lower incidence. With in-creasing doses multiple regional defects were increased while single regional defects declined. The types of malformations were described.