Decrease in Cleft Lip Incidence by Urethane Administration to CL/Fr Mice

Abstract

A significant decrease in the incidence of cleft lip without change in embryonic mortality was observed in CL/Fr mice by administering 100 to 500 mg/kg of urethane to dams on day 9 of gestation. No significant change in cleft lip incidence was observed when treated on day 8 and 10.