Ultraviolet Sensitivity of Cockayne Syndrome and Its Heterozygotes : Cell Biological Diagnosis of Atypical Case

Abstract

Ultraviolet (UV) sensitivity of cultured skin fibroblasts derived from heterozygotes and patients with Cockayne syndrome (CS) was measured in terms of counting survival colonies. UV sensitivity of CS heterozygotes was ranged between normal control and CS patients significantly. Measurement of UV sensitivity is one of the useful methods for the detection of carrier or atypical CS patients in family with overt CS patient.