Abstract
It was the 11th SIDS, the Screening Information Data Set, Initial Assessment Meeting (SIAM-11, held at Orland, USA) where the initial assessment documents prepared by the International Council of Chemical Associations (ICCA) for the first time were reviewed by the authorities. In this report, the brief summary of the document for 6,6'-di-tert-Butyl-2,2'-methylene di-p-cresol submitted by Sumitomo Chemical Co., Ltd. is introduced. During the review process, the theoretical investigations on the uptake limitations of this substance to aquatic organisms in relation to the steric effect of the molecule were additionally made since the validity of the test results with aquatic organisms was suspected by the authorities. The outline of this discussion on the bioavailability of the substance in water is also introduced.
