1967 Volume 15 Issue 2 Pages 122-126
?Thiophenicol was administered to infant and adult patients who had various infectious diseases in our surgical wards, and this drug was proved to be effective in 73% of the cases.
Only the minimal side effects in the digestive tract were noted, and no disturbances of the hematopoetic or hepatic functions were found.
The pathogenic staphylococci is olated from the infectious foci of the patients appeared to be rather less sensitive against thiophenicol, as compared with chloramphenicol.
The pathogenic gram negative bacilli, particularly E. coli or Proteus, were shown to have a greater number of the resistant strains to thiophenicol than to chloramphenicol. Thiophenicol showed higher level in blood and kept an effective serum concentration longer period by the single administration of 500 mg. p. o., in comparison with chloramphenicol.
Thiophenicol was not any longer detected in blood three hours a fter the intramuscular injection in adults, also almost the equal results of the above were obtained in infant.
The amount of the urinary excretion of thiophenicol was found to be far greater than that of chloramphenicol and hence thiophenicol was expected to be useful in urinary tract infection.
