Abstract
In vitro antitrichomonal activities of 171 nitr ofuran compounds having various chemical structures: were tested.
It w as found that heterocyclic vinyl compounds exhibited the superior antitrichomonal activity as well. as the superior antibacterial and antimycotic activities. The relationship between structure and activity of these compounds - was discussed and following results were shown.
1) The 5-nitro group was essential for the activity.
2) Being irrespective of conversion of N to N-oxide, the activity was markedly reduced by conversion of tertiary N to quaternary ammonium salt on heterocycles containing N.
3) Substitution in the 1-position of the vinyl chain reduced the activity.
4) Nitrothiophene compounds showed the similar activity to nitro furan compounds.
5) Acetylation of an amino group in heterocycles did not decrease the activity but increase it im some cases
