Abstract
In vitro antimycotic activities of 171 nitrofura n compounds having various chemical structures were tested.
It was found that heterocyclic vinyl compounds exhibited the superior antimycotic activity as well as the superior antibacterial activity. The relationship between structure and activity of these compounds was discussed and following results were shown.
1) The 5-nitro group was essential for the activ ity.
2) Substitution of the other ring for the fura n ring markedly reduced the activity.
3) Conversion of tertiary N on heterocycles to quaternary ammonium salt r educed the activity.
4) Substitution in the 1-position of the vinyl chain reduced the activity.
5) Benzheterocycle compounds except for quinolines were less act ive than the corresponding heterocycle compounds.
6) Conversion of N on a pyridine ring to N-oxide reduced the activity.
7) When a heterocycle was a pyrimidine, the activity was weak.
