Abstract
Distribution of sulfamethoxypyrazine (SMP) by oral administration in human (1 gjman) and in aniraat (100 m g/kg) was observed in comparison with suLfadimethoxine (SDM) and sulfisomezole (SIM). The results of Report II are summarized as follows.
1) Blood levels of SMP in men were sh o wn by the occurrence of peak value (45 m cgiml) in 5 hours, and this was foliwed by the slow disappearance as well as SDM, but the concentration in each time was higher than SDM and SIM.
2) In the case of SMP and SDM, a bout 20% of the administered dose were excreted in the human, urine in 24 hours, but on the contrary SIM showed the recovery of more than 90%.
3) Bile concentrations of SMP in rats were as high as SIM and more than th ose of SDM.
4) Tissue distributions of SMP in rabbits showed similar pattern with SDM.
