6-Methylen-5-hydroxy-tetracyclineに関する研究
1968 年 16 巻 1 号 p. 56-61
詳細
1968 年 16 巻 1 号 p. 56-61
On methylen-5-hydroxy-tetracycline (MOTC), one of the tetracycline derivatives, fundamental and clinical studies were carried out comparing with three other tetracyclines and the following resultswere obtained.
1. Staphylococcus aureus and variety of gram negative bacilli showed generally similar sensitivities against all four tetracyclines. There were complete cross resistances each other.
2. MOTC received the least inactivation by any of Ca, Mg and Al cations whe n tested using CaCl2. MgSO3 and KA1(SO4)2 solutions.
3. It was concluded that MOTC was much adsorbed by red blood corpuscle and inactivated by mice liver homogenate in the middle grade. The serum protein binding rate was calculated as much as. 53% on average by cellophane bag dialysis method.
4. The organ level of mice following ora l administration of MOTC showed lower value on the whole than TC, being especially great the difference in that of liver.
5. There was comparable inhibitory effect of MOTC to TC against abscess formation following the subcutaneous inoculation of Staphylococcus aureus into the back of mice. Four tetracyclines were considered to be equally effective on the next such experiment.
6. Two cases of one pyelonephritis and anothe r bronchiectasia were treated by MOTC. The former was cured, but in the latter the temporal improvement was followed by deterioration perhaps due to, the change af bacterial flora, in spite of continuation of MOTC treatment.
