1. Sensitivity:
More than 3/4 of test strains of coagulase positive Staphylococcuasn d E. coli were sensitive against aminosidine at the concentration below 6. 3 mcg/ml. The sensitivity against aminosidine was higher than that against SM which was determined at the same time.
2. Blood level:
When injec ted to normal adults intramuscularly, aminosidine showed high blood level. When it was once administered at a dose of 500 mg, its blood level reached the peak (18. 1 mcg/ml) after 2 hours and reduced to 3. 9 mcg/ml after 6 hours.
3. Excretion into urine:
The concentration of aminosidine in urine was very high. Urinary recovery rate was 87. 3 % in the first 12 hours.
4. Renal excretion mechanism:
Renal excretion mech anism was examined with Stop-flow method. As a result, glomerular filtration, absorption at superior renal tubule and secretion at inferior renal tubule were observed.
5. Nephrotoxicity:
After aminosidine was administered to rats and rabbits continuously, renal function and renal tissue findings were examined. Nephrotoxicity of aminosidine is comparatively slight and seems to be more slight than that of CL.
6. Clinical resul ts:
Aminosidine was administered to 7 cases of internal infections. In 5 cases of them, aminosidine was proved to be effective.
7. Side eff ects:
Only in o ne case of the 7 cases given aminosidine, topalgia and slight palsy at the injected place were observed. In other 6 cases, no side effects were observed.
