This report relates to some fundamental evaluation of aminobenzyl penicillin (AB-PC) in particular reference to the urinary tract infection.
(1) Absorption and excretion:
The urinary concentration of the drug is relatively high. When administered orally in 500 mg or intramuscularly in a single dosage of 250 mg the urinary recovery at 6 hours was approximately 68%.
The organ concentration of the drug was determined in rats and was found to be highest in the kidneys followed by the liver, blood, lungs and spleen in order, indicative of its specific affinity to the kidneys.
(2) Sensitivity of AB-PC to E. coli:
The sensitivity of the drug to E. coli isolated from the patients with urinary tract infection lies in the range of 1. 6 to 100 mcg/ml with its peak sensitivity at 3. 2 to 6. 3 mcg/ml.
(3) Clinical data:
(a) The effect in urinary tract infections;
The effect of AB-PC was studied in 11 patie n ts with acute or chronic pyelonephritis in whom 6 improved remarkably, 2 mild to moderately and the rest little or none.
(b) The effect of AB-PC to E. coli pyelonephritis:
When administered to E. coli pyelonephritis, the req u ired period for the disappearance of bacteriuria was not significantly different from that of NA, CER, and KM, however the period for impra ving the urinary sediments was difinitely shorter in AB-PC as compared to NA but slower than that by KM and CER.
